MA5-15654 targets KLHL21 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15654 immunogen is purified recombinant fragment of human KLHL21 expressed in E. Coli.
MA5-15654 detects KLHL21 which has a predicted molecular weight of approximately 66kDa.
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
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Protein Aliases: kelch-like family member 21; Kelch-like protein 21; MGC99635
Gene Aliases: KIAA0469; KLHL21
UniProt ID: (Human) Q9UJP4
Entrez Gene ID: (Human) 9903