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Invitrogen
P-Selectin Monoclonal Antibody (Psel.KO.2.12)
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Product Details
MA5-16922
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Goat,
Human,
Sheep,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Psel.KO.2.12
Immunogen
CD62P transfected 300.19 cells.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; FLJ45155; GMP-140; Granule membrane protein 140; granule membrane protein 140kDa; granule membrane protein-140 (GMP-140) precursor; granulocyte membrane protein; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; RP1-86F14.2; selectin P (granule membrane protein 140kDa antigen CD62) isoform SELP_1; selectin P (granule membrane protein 140kDa antigen CD62) isoform SELP_3; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; unnamed protein product
Gene Aliases: CD62; CD62P; GMP140; GMRP; GRMP; LECAM3; PADGEM; PSEL; PSELECT; SELP
UniProt ID: (Human) P16109, (Sheep) P98109, (Rat) P98106
Entrez Gene ID: (Goat) 102170076, (Human) 6403, (Sheep) 443305, (Rat) 25651
positive regulation of leukocyte migration
regulation of cellular extravasation
inflammatory response
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
positive regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
single organismal cell-cell adhesion
response to lipopolysaccharide
regulation of integrin activation
positive regulation of cell adhesion
blood vessel morphogenesis
leukocyte migration
leukocyte tethering or rolling
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
response to cytokine
defense response to Gram-negative bacterium
positive regulation of protein kinase B signaling
cell-cell adhesion
cell-cell adhesion via plasma-membrane adhesion molecules
positive regulation of leukocyte tethering or rolling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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