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Invitrogen
KChIP2 Monoclonal Antibody (OTI3D8)
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Product Details
MA5-26866
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3D8
Immunogen
Full length human recombinant protein of KCNIP2 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP; KChIP2; KCHIP2.2; KChlP2; KCNIP2-Ia; KCNIP2-Ia#IIab; KCNIP2-Ia#IIb; KCNIP2-Ib#IIab; KCNIP2-Ic#IIab; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; neuronal calcium sensor-1 homolog; potassium channel interacting protein; KChIP2; Potassium channel-interacting protein 2; unnamed protein product
Gene Aliases: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61
Entrez Gene ID: (Human) 30819
action potential
detection of calcium ion
ion transport
potassium ion transport
muscle contraction
signal transduction
chemical synaptic transmission
regulation of heart contraction
regulation of signal transduction
ion transmembrane transport
clustering of voltage-gated potassium channels
regulation of membrane repolarization
potassium ion transmembrane transport
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
regulation of potassium ion export across plasma membrane
positive regulation of potassium ion export across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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