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Invitrogen
TRPC5 Monoclonal Antibody (N67/15)
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FIGURE: 1 / 2
TRPC5 Antibody (MA5-27657) in IHC (P)
Immunohistochemistry analysis of TRPC5 in mouse brain. Samples were incubated with TRPC5 monoclonal antibody (Product # MA5-27657) using a dilution of 1:1000 (1 hour at RT) and followed by Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) and Mayer Hematoxylin (purple/blue) at a dilution of 250-500 µl. Magnification: 10X.
Product Details
MA5-27657
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N67/15
Immunogen
Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Formerly sold as clone (S67/15).
1 µg/mL of MA5-27657 was sufficient for detection of TrpC5 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 110kDa.
Target Information
TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Capacitative calcium entry channel 2; CCE2; Htrp-5; hTRP5; mtrp5; protein phosphatase 1, regulatory subunit 159; Short transient receptor potential channel 5; transient receptor potential channel 5; Transient receptor protein 5; TRP-5; Trp-related protein 5; TrpC5; vtransient receptor potential cation channel, subfamily C, member 5
Gene Aliases: CCE2; PPP1R159; TRP-5; TRP5; TRPC5; Trrp5
UniProt ID: (Human) Q9UL62, (Mouse) Q9QX29
Entrez Gene ID: (Human) 7224, (Mouse) 22067, (Rat) 140933
ion transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
nervous system development
positive regulation of cell proliferation
neuron differentiation
ion transmembrane transport
positive regulation of neuron differentiation
positive regulation of axon extension
negative regulation of dendrite morphogenesis
neuron apoptotic process
regulation of cytosolic calcium ion concentration
transmembrane transport
calcium ion transmembrane transport
phosphatidylserine exposure on apoptotic cell surface
regulation of membrane hyperpolarization
transport
manganese ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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