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Invitrogen
CD226 (DNAM-1) Monoclonal Antibody (DX11)
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FIGURE: 1 / 1
CD226 (DNAM-1) Antibody (MA5-28152) in Flow
Flow cytometry of CD226 (DNAM-1) in red cell lysed human blood. Sample was incubated in the presence of 10% dog serum, CD226 (DNAM-1) monoclonal antibody (Product # MA5-28152) and gated on lymphoid cells. Figures are arranged as follows: A) Alexa Fluor 488 conjugated Mouse anti Human CD3 and PE-Alexa Fluor 647 conjugated Mouse IgG1 isotype control. B) Alexa Fluor 488 conjugated Mouse anti Human CD3 and PE-Alexa Fluor 647 conjugated Mouse anti Human CD226.
Product Details
MA5-28152
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
DX11
Immunogen
Human cytotoxic T lymphocyte clone
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes human CD226, approximately a 65 kDa glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells.
Target Information
DNAM 1 is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion glycoprotein; CD226; CD226 antigen; DNAM 1; DNAM-1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen; unnamed protein product
Gene Aliases: CD226; DNAM-1; DNAM1; PTA1; TLiSA1
UniProt ID: (Human) Q15762
Entrez Gene ID: (Human) 10666
positive regulation of natural killer cell cytokine production
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cell adhesion
signal transduction
cell recognition
positive regulation of interferon-gamma production
positive regulation of mast cell activation
natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of T cell receptor signaling pathway
positive regulation of Fc receptor mediated stimulatory signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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