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Invitrogen
KIR2DL4 Monoclonal Antibody (mAb#33), APC
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Product Details
MA5-28573
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
mAb#33
Immunogen
NK3.3 cells and KIR2DL4-Ig fusion protein
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.
Target Information
CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD158 antigen-like family member D; CD158d; G9P; Ig1-TM10A; Ig1-TM10A truncated; Ig2-TM9A Del; Killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; Killer cell inhibitory receptor 103AS; killer cell inhibitory receptor homolog; KIR homolog; KIR-103AS; KIR2DL4; KIR2DL4 Killer-cell Immunoglobulin-like Receptor; KIR2DL4*00102; KIR2DL4*00103; KIR2DL4*00501; KIR2DL4*00801; KIR2DL4*00802; KIR2DL4*01101; KIR2DL4*021; KIR2DL4*022; KIR2DL4_00201; KIR2DL4_00201 protein; MHC class I NK cell receptor KIR103AS; natural killer cell receptor; NK cell receptor; CD158d; short cytoplasmic tail variant
Gene Aliases: CD158D; G9P; KIR-103AS; KIR-2DL4; KIR103; KIR103AS; KIR2DL4
UniProt ID: (Human) Q99706
Entrez Gene ID: (Human) 3805
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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