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Invitrogen
LARGE Monoclonal Antibody (LARGE-02)
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FIGURE: 1 / 1
LARGE Antibody (MA5-28611) in Flow
Separation of Hek293 cells transfected with LARGE1 vector and stained using anti-LARGE1 (LARGE-02) purified Monoclonal antibody (Product # MA5-28611), concentration in sample 15 µg/mL (GAM APC, red-filled) from Hek293 cells transfected with LARGE1 and unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (intracellular staining).
Product Details
MA5-28611
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
LARGE-02
Immunogen
Human LARGE1 (amino acids 35-142)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Cross reactivity with LARGE2 was not determined.
Target Information
The LARGE gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; Glycosyltransferase-like protein; glycosyltransferase-like protein LARGE1; LARGE; LARGE xylosyl- and glucuronyltransferase 1; like-acetylglucosaminyltransferase; unnamed protein product; Xylosyl- and glucuronyltransferase LARGE1
Gene Aliases: KIAA0609; LARGE; LARGE1; MDC1D; MDDGA6; MDDGB6
UniProt ID: (Human) O95461
Entrez Gene ID: (Human) 9215
catalytic activity
protein binding
acetylglucosaminyltransferase activity
glucuronosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
manganese ion binding
UDP-xylosyltransferase activity
xylosyltransferase activity
metal ion binding
blood vessel development
behavioral fear response
neuron migration
N-acetylglucosamine metabolic process
protein glycosylation
protein O-linked glycosylation
protein targeting to membrane
glycosphingolipid biosynthetic process
water transport
intracellular protein transport
striated muscle contraction
plasma membrane organization
cytoskeleton organization
chemical synaptic transmission
neuromuscular synaptic transmission
brain development
heart development
muscle organ development
neuromuscular junction development
sensory perception of sound
memory
protein localization
determination of adult lifespan
glycoprotein metabolic process
glycoprotein biosynthetic process
response to light stimulus
response to mechanical stimulus
gene expression
retina layer formation
myotube differentiation
dentate gyrus development
nerve development
principal sensory nucleus of trigeminal nerve development
macrophage differentiation
post-embryonic hindlimb morphogenesis
multicellular organism growth
protein O-linked mannosylation
protein modification process
myelination
skeletal muscle tissue regeneration
post-translational protein modification
muscle cell cellular homeostasis
regulation of synaptic plasticity
astrocyte differentiation
cardiac muscle tissue development
skeletal muscle fiber development
synapse organization
neuromuscular process controlling posture
neuromuscular process
synaptic growth at neuromuscular junction
localization of cell
striated muscle cell development
cardiac muscle cell development
transmembrane transport
retina development in camera-type eye
limb development
long-term synaptic potentiation
bone development
skeletal muscle organ development
retina vasculature development in camera-type eye
connective tissue development
protein-containing complex assembly
basement membrane organization
potassium ion transmembrane transport
protein localization to membrane
protein localization to plasma membrane
walking behavior
acetylcholine receptor signaling pathway
skeletal muscle fiber differentiation
reactive gliosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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