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Phospho-MAP2K4 (Ser257) Recombinant Rabbit Monoclonal Antibody (SEK1MKK4S257-C5), PE
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FIGURE: 1 / 1
Phospho-MAP2K4 (Ser257) Antibody (MA5-37138) in Flow
Flow cytometry of Phospho-MAP2K4 (Ser257) using 293T cells. Samples were incubated in monoclonal Phospho-MAP2K4 (Ser257) antibody (Product # MA5-37138). Images correspond with the following conditions: treated with lambda phosphatase (black), treated with UV/TPA (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37138
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SEK1MKK4S257-C5
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-JUN N-terminal kinase kinase 1; c-Jun NH2-terminal kinase kinase 1; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; MAP kinase kinase 4; MAP2K4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; stress-activated protein kinase kinase 1; unnamed protein product
Gene Aliases: JNKK; JNKK1; MAPKK 4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
UniProt ID: (Human) P45985, (Mouse) P47809
Entrez Gene ID: (Human) 6416, (Mouse) 26398
MAPK cascade
positive regulation of protein phosphorylation
protein phosphorylation
cell surface receptor signaling pathway
JNK cascade
neuromuscular junction development
response to wounding
cellular response to stress
smooth muscle cell apoptotic process
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
ERBB signaling pathway
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of DNA replication
positive regulation of JNK cascade
cell growth involved in cardiac muscle cell development
cellular response to mechanical stimulus
negative regulation of motor neuron apoptotic process
signal transduction
Fc-epsilon receptor signaling pathway
cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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