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Invitrogen
Phospho-Lyn (Tyr507) Recombinant Rabbit Monoclonal Antibody (LynY507-5B6), PE
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Product Details
MA5-37170
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
LynY507-5B6
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr507 of human phospho Lyn.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ26625; lck/Yes-related novel protein tyrosine kinase; lyn; lyn tyrosine kinase; protein-tyrosine kinase (EC 2.7.1.112); unnamed protein product; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Gene Aliases: Hck-2; JTK8; p53Lyn; p56Lyn; SAIDV
UniProt ID: (Human) P07948, (Mouse) P25911
Entrez Gene ID: (Human) 4067, (Mouse) 17096
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
platelet-derived growth factor receptor binding
integrin binding
protein binding
ATP binding
kinase activity
enzyme binding
receptor activator activity
ubiquitin protein ligase binding
immunoglobulin receptor binding
gamma-tubulin binding
glycosphingolipid binding
ion channel binding
macromolecular complex binding
ephrin receptor binding
phosphoprotein binding
scaffold protein binding
phosphorylation-dependent protein binding
erythropoietin receptor binding
SH3 domain binding
phosphatidylinositol 3-kinase activator activity
DNA damage checkpoint
cell morphogenesis
B cell homeostasis
regulation of cytokine production
negative regulation of protein phosphorylation
hematopoietic progenitor cell differentiation
Fc receptor mediated stimulatory signaling pathway
tolerance induction to self antigen
histamine secretion by mast cell
platelet degranulation
negative regulation of myeloid leukocyte differentiation
immune response-regulating cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
regulation of B cell apoptotic process
protein phosphorylation
autophagy
defense response
inflammatory response
cellular response to DNA damage stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
response to hormone
positive regulation of neuron projection development
fatty acid transport
vesicle-mediated transport
peptidyl-tyrosine phosphorylation
hemopoiesis
erythrocyte differentiation
eosinophil differentiation
positive regulation of cell migration
negative regulation of B cell proliferation
neuron projection development
lipopolysaccharide-mediated signaling pathway
regulation of mast cell activation
regulation of cell adhesion mediated by integrin
negative regulation of toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
intracellular signal transduction
interleukin-5-mediated signaling pathway
C-X-C chemokine receptor CXCR4 signaling pathway
B cell proliferation
positive regulation of phosphorylation
hemoglobin biosynthetic process
regulation of mast cell degranulation
negative regulation of MAP kinase activity
positive regulation of MAPK cascade
regulation of erythrocyte differentiation
protein autophosphorylation
ephrin receptor signaling pathway
regulation of inflammatory response
B cell receptor signaling pathway
regulation of B cell receptor signaling pathway
negative regulation of B cell receptor signaling pathway
regulation of release of sequestered calcium ion into cytosol
positive regulation of glial cell proliferation
positive regulation of Fc receptor mediated stimulatory signaling pathway
regulation of ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
positive regulation of oligodendrocyte progenitor proliferation
negative regulation of mast cell proliferation
positive regulation of mast cell proliferation
cellular response to retinoic acid
regulation of monocyte chemotaxis
regulation of platelet aggregation
dendritic cell differentiation
neuroinflammatory response
negative regulation of intracellular signal transduction
positive regulation of amyloid precursor protein catabolic process
positive regulation of protein localization to plasma membrane
positive regulation of dendritic cell apoptotic process
regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
innate immune response-activating signal transduction
negative regulation of inflammatory response to antigenic stimulus
response to sterol depletion
signal transduction
response to xenobiotic stimulus
response to toxic substance
response to carbohydrate
oligodendrocyte development
T cell costimulation
response to insulin
cellular response to heat
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to amino acid
response to peptide hormone
response to axon injury
negative regulation of immune response
leukocyte migration
JAK-STAT cascade involved in growth hormone signaling pathway
cellular response to lipid
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