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Invitrogen

HSP90 Monoclonal Antibody (D7A), APC

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HSP90 Monoclonal Antibody (D7A), APC

Product Details

MA5-45157

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:100,000
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

5 µg
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Bovine, Chicken, Human, Mouse, Pig, Rabbit, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

D7A

Immunogen

Full length protein HSP90 purified from chicken brain
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.2, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931611

Product Specific Information

2 µg/mL was sufficient for detection of HSP90 alpha in 20 µg of heat shocked HeLa cell lysate as well as in 100 ng of human HSP90 alpha protein by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.|Recognizes 90kDa.approximately Can isolate complexes of HSP90, Src kinase and cec37.

Target Information

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 90-kDa heat shock protein; ATHS83; AtHsp90-1; ATHSP90.1; F6N7.13; F6N7_13; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; HEAT SHOCK PROTEIN 81-1; HEAT SHOCK PROTEIN 83; heat shock protein 86; heat shock protein 90 beta; HEAT SHOCK PROTEIN 90-1; heat shock protein 90.1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP81-1; HSP81.1; HSP83; HSP84; HSP86; hsp90 beta; LAP-2; Lipopolysaccharide-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen

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Gene Aliases: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; hsp4; Hsp84; Hsp84-1; Hsp86; Hsp86-1; Hsp89; HSP90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPC3; HSPCA; HSPCB

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UniProt ID: (Chicken) P11501, (Bovine) Q76LV2, (Pig) O02705, (Bovine) Q76LV1, (Rabbit) P30947, (Mouse) P07901, (Rat) P82995, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Chicken) 423463, (Bovine) 281832, (Pig) 397028, (Rabbit) 100338694, (Chicken) 396188, (Bovine) 767874, (Pig) 396742, (Rabbit) 100358690, (Mouse) 15519, (Rat) 299331, (Mouse) 15516, (Rat) 301252

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Function(s)
ATP binding protein C-terminus binding ATPase activity nitric-oxide synthase regulator activity estrogen receptor binding TPR domain binding heat shock protein binding progesterone receptor binding identical protein binding virion binding unfolded protein binding chaperone binding Hsp90 protein binding disordered domain specific binding protein binding protein homodimerization activity protein dimerization activity double-stranded RNA binding protein kinase regulator activity protein kinase binding ubiquitin protein ligase binding peptide binding histone deacetylase binding ATP-dependent protein binding protein binding involved in protein folding tau protein binding DNA polymerase binding histone methyltransferase binding nucleotide binding UTP binding CTP binding mRNA binding GTP binding sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding dATP binding ion channel binding poly(A) RNA binding GTPase binding Rho GDP-dissociation inhibitor binding kinase binding Hsp90 family chaperone
Process(es)
protein folding positive regulation of cell proliferation response to heat response to cold response to organonitrogen compound response to organic cyclic compound response to progesterone cellular response to heat positive regulation of nitric oxide biosynthetic process response to antibiotic regulation of catalytic activity protein stabilization positive regulation of cell cycle G2/M phase transition positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of cell cycle arrest negative regulation of transforming growth factor beta activation placenta development telomere maintenance via telomerase virion attachment to host cell central nervous system neuron axonogenesis establishment of cell polarity regulation of protein ubiquitination positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process positive regulation of cell differentiation axon extension chaperone-mediated protein complex assembly positive regulation of protein kinase B signaling positive regulation of telomerase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to interleukin-4 fibril organization positive regulation of cyclin-dependent protein kinase activity telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface neuron migration nitric oxide biosynthetic process response to stress response to unfolded protein positive regulation of lamellipodium assembly positive regulation of protein import into nucleus, translocation protein refolding protein import into mitochondrial outer membrane positive regulation of cytotoxic T cell differentiation positive regulation of cell size skeletal muscle contraction response to salt stress cardiac muscle cell apoptotic process response to estrogen positive regulation of cardiac muscle contraction positive regulation of protein binding negative regulation of neuron apoptotic process positive regulation of protein serine/threonine kinase activity cellular response to organic cyclic compound
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