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Invitrogen
DNMT1 Monoclonal Antibody (4G11-C7), PerCP
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Product Details
MA5-45296
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fish,
Human,
Mouse,
Zebrafish
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4G11-C7
Immunogen
Raised against a partial protein corresponding to amino acids 620-950 of human DNMT1
Conjugate
PerCP
PerCP
PerCP
Excitation/Emission Max
482/675 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
2 µg/mL of MA5-45296 was sufficient for detection of Dnmt1 in 10 µg of mouse ES cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 180kDa. It will cross-react with mouse DNMT1.
Target Information
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA methyltransferase MmuI; DNA MTase HsaI; DNA MTase MmuI; DNMT1; FLJ16293; MCMT; MGC104992; unnamed protein product
Gene Aliases: ADCADN; AIM; cb1075; cb983; CXXC9; ddn; dmnt1; DNMT; DNMT1; Dnmt1o; fb05h01; HSN1E; m.HsaI; m.MmuI; MCMT; Met-1; Met1; MommeD2; mta; MTase; Uim; wu:fb05h01
UniProt ID: (Human) P26358, (Mouse) P13864
Entrez Gene ID: (Human) 1786, (Mouse) 13433, (Zebrafish) 30430
DNA binding
chromatin binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
methyltransferase activity
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
transferase activity
metal ion binding
lncRNA binding
promoter-specific chromatin binding
double-stranded DNA binding
catalytic activity
transcription factor binding
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
DNA metabolism protein
DNA methyltransferase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
methylation
regulation of cell proliferation
DNA methylation involved in embryo development
hypermethylation of CpG island
negative regulation of transcription, DNA-templated
cellular response to amino acid stimulus
chromosomal DNA methylation maintenance following DNA replication
cellular response to bisphenol A
positive regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell apoptotic process
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
DNA methylation
regulation of transcription, DNA-templated
metabolic process
maintenance of DNA methylation
DNA methylation on cytosine within a CG sequence
gene silencing
chromatin modification
DNA methylation on cytosine
response to antidepressant
DNA hypermethylation
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
liver development
lens development in camera-type eye
determination of left/right symmetry
retina layer formation
pancreas development
exocrine pancreas development
intrahepatic bile duct development
regulation of DNA methylation
digestive tract development
cartilage development
histone H3-K9 methylation
retina morphogenesis in camera-type eye
definitive hemopoiesis
Kupffer's vesicle development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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