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Invitrogen
CD105 Recombinant Rabbit Monoclonal Antibody (103), FITC
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FIGURE: 1 / 2
CD105 Antibody (MA5-46642) in Flow
Flow cytometry analysis of CD105 (Endoglin) in HUVEC cells using CD105, FITC Recombinant Monoclonal (Product # MA5-46642) (solid line fluorescence histogram) or a negative control at a matching concentration (dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells.
Product Details
MA5-46642
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
103
Immunogen
Recombinant protein ecoding Human CD105 (Met1-Gly586).
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD105 (Endoglin) (Met1-Gly586) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Target Information
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD105; CD105 antigen; circulating isoform of endoglin TGF-beta receptor type III; Endoglin; endoglin precursor; ORW; soluble endoglin; unnamed protein product
Gene Aliases: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
transmembrane signaling receptor activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
coreceptor activity
receptor activator activity
type I transforming growth factor beta receptor binding
BMP binding
identical protein binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
vasculogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
heart looping
sprouting angiogenesis
positive regulation of systemic arterial blood pressure
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
transforming growth factor beta receptor signaling pathway
heart development
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
regulation of cell adhesion
negative regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
dorsal aorta morphogenesis
wound healing
regulation of cell proliferation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
positive regulation of protein kinase B signaling
atrial cardiac muscle tissue morphogenesis
cell chemotaxis
positive regulation of SMAD protein import into nucleus
negative regulation of SMAD protein import into nucleus
detection of hypoxia
endocardial cushion to mesenchymal transition
vascular smooth muscle cell development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of vascular smooth muscle cell differentiation
atrioventricular canal morphogenesis
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of cell proliferation involved in heart morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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