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COMP is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cartilage oligomeric matrix protein; COMP; MGC131819; MGC149768; thrombospondin-5; Thrombospondin5; TSP 5
Gene Aliases: Comp; TSP5
UniProt ID: (Mouse) Q9R0G6
Entrez Gene ID: (Mouse) 12845
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