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Invitrogen

ITGA5/ITGB1 (Volociximab Biosimilar) Recombinant Human Monoclonal Antibody (M200 (Volociximab))

View all (10) ITGA5/ITGB1 antibodies

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Product Details

MA5-51585

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Inhibition Assays (Inhibition)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG4, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

M200 (Volociximab)

Immunogen

Heterodimeric Human alpha 5 Beta 1 Fc fusion protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3250286

Product Specific Information

The antibody binds to human alpha 5 Beta 1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.

MA5-51585 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD29; CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; Fibronectin receptor subunit beta; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; Glycoprotein IIa; GPIIA; Integrin alpha-5; Integrin alpha-F; integrin beta 1; Integrin beta-1; integrin beta-1 subunit (cytoplasmic domain); Integrin beta1; integrin VLA-4 beta subunit; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITGA5/SLC9B1 fusion; surface glycoprotein receptor; unnamed protein product; very late activation protein 5, alpha subunit; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLA-5

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Gene Aliases: CD29; CD49e; FNRA; FNRB; GPIIA; ITGA5; ITGB1; MDF2; MSK12; VLA-5; VLA-BETA; VLA5A; VLAB

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UniProt ID: (Human) P08648, (Human) P05556

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Entrez Gene ID: (Human) 3678, (Human) 3688

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Function(s)
virus receptor activity receptor binding epidermal growth factor receptor binding platelet-derived growth factor receptor binding integrin binding calcium ion binding protein binding signaling receptor activity vascular endothelial growth factor receptor 2 binding metal ion binding cell adhesion molecule binding magnesium ion binding fibronectin binding protease binding actin binding coreceptor activity protein kinase binding C-X3-C chemokine binding laminin binding macromolecular complex binding cadherin binding protein heterodimerization activity collagen binding involved in cell-matrix adhesion integrin binding involved in cell-matrix adhesion protein tyrosine kinase binding
Process(es)
angiogenesis formation of primary germ layer cell-substrate junction assembly cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion integrin-mediated signaling pathway female pregnancy memory tissue development positive regulation of cell-substrate adhesion response to muscle activity CD40 signaling pathway positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion wound healing, spreading of epidermal cells endodermal cell differentiation regulation of angiogenesis viral entry into host cell cell-cell adhesion positive regulation of vascular endothelial growth factor signaling pathway positive regulation of sprouting angiogenesis negative regulation of anoikis G1/S transition of mitotic cell cycle establishment of mitotic spindle orientation in utero embryonic development cell migration involved in sprouting angiogenesis positive regulation of neuroblast proliferation phagocytosis cellular defense response homophilic cell adhesion via plasma membrane adhesion molecules calcium-independent cell-matrix adhesion transforming growth factor beta receptor signaling pathway neuroblast proliferation muscle organ development myoblast fusion cell proliferation germ cell migration visual learning regulation of collagen catabolic process positive regulation of fibroblast migration cell migration formation of radial glial scaffolds central nervous system neuron differentiation cell projection organization lamellipodium assembly B cell differentiation extracellular matrix organization neuron projection development receptor internalization negative regulation of Rho protein signal transduction maintenance of blood-brain barrier positive regulation of apoptotic process stress fiber assembly positive regulation of GTPase activity sarcomere organization myoblast differentiation negative regulation of neuron differentiation positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis negative regulation of vasoconstriction mesodermal cell differentiation myoblast fate specification axon extension dendrite morphogenesis regulation of developmental process modulation of synaptic transmission leukocyte tethering or rolling regulation of cell cycle positive regulation of protein kinase B signaling positive regulation of glutamate uptake involved in transmission of nerve impulse cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation cardiac cell fate specification regulation of biological quality cellular response to low-density lipoprotein particle stimulus basement membrane organization positive regulation of wound healing regulation of spontaneous synaptic transmission reactive gliosis positive regulation of protein localization to plasma membrane regulation of synapse pruning
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