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PDGFRB Recombinant Rabbit Monoclonal Antibody (206), FITC
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FIGURE: 1 / 1
PDGFRB Antibody (MA5-52220) in Flow
Flow cytometry analysis of Human PDGFR beta (CD140b) expression on MG63 cells. Samples were incubated with PDGFRB monoclonal antibody (Product # MA5-52220). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Product Details
MA5-52220
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
206
Immunogen
Recombinant Human PDGFRB/CD140b protein (1-531).
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activated tyrosine kinase PDGFRB; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; NDEL1-PDGFRB; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide; unnamed protein product
Gene Aliases: CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT
UniProt ID: (Human) P09619
Entrez Gene ID: (Human) 5159
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
platelet activating factor receptor activity
platelet-derived growth factor-activated receptor activity
platelet-derived growth factor beta-receptor activity
GTPase activator activity
receptor binding
platelet-derived growth factor receptor binding
protein binding
ATP binding
kinase activity
transferase activity
enzyme binding
protein kinase binding
vascular endothelial growth factor binding
platelet-derived growth factor binding
phospholipase C activator activity
angiogenesis
chemotaxis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
smooth muscle adaptation
positive regulation of smooth muscle cell migration
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
regulation of actin cytoskeleton organization
cell migration involved in vasculogenesis
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
aorta morphogenesis
cellular response to platelet-derived growth factor stimulus
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of MAP kinase activity
positive regulation of mitotic nuclear division
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
positive regulation of smooth muscle cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of chemotaxis
positive regulation of protein kinase B signaling
cardiac myofibril assembly
cell chemotaxis
cell migration involved in coronary angiogenesis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
smooth muscle cell chemotaxis
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric glomerular capillary formation
positive regulation of calcium ion import
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
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