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Invitrogen
CX3CL1 Recombinant Rabbit Monoclonal Antibody (409), HRP
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Product Details
MA5-52228
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
409
Immunogen
Recombinant Human Fractalkine/CX3CL1 protein (1-339).
Conjugate
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; Fractalkine; Neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; Small-inducible cytokine D1; unnamed protein product
Gene Aliases: A-152E5.2; ABCD-3; C3Xkine; CX3CL1; CXC3; CXC3C; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1
UniProt ID: (Human) P78423
Entrez Gene ID: (Human) 6376
microglial cell activation
positive regulation of cell-matrix adhesion
positive regulation of neuroblast proliferation
leukocyte migration involved in inflammatory response
response to ischemia
chemotaxis
defense response
inflammatory response
immune response
cell adhesion
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
negative regulation of cell-substrate adhesion
positive regulation of neuron projection development
neuron remodeling
cytokine-mediated signaling pathway
positive regulation of cell migration
negative regulation of cell migration
neutrophil chemotaxis
leukocyte chemotaxis
regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of actin filament bundle assembly
negative regulation of interleukin-1 alpha production
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of transforming growth factor beta1 production
integrin activation
autocrine signaling
wound healing
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
eosinophil chemotaxis
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
regulation of neurogenesis
leukocyte adhesive activation
positive chemotaxis
positive regulation of calcium-independent cell-cell adhesion
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of protein kinase B signaling
angiogenesis involved in wound healing
cell chemotaxis
microglial cell proliferation
antimicrobial humoral immune response mediated by antimicrobial peptide
neuron cellular homeostasis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
extrinsic apoptotic signaling pathway in absence of ligand
cell-cell adhesion
synapse pruning
negative regulation of hippocampal neuron apoptotic process
negative regulation of glutamate receptor signaling pathway
negative regulation of microglial cell activation
positive regulation of microglial cell migration
negative regulation of neuron migration
negative regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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