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Invitrogen

Phospho-C-Jun/D-Jun (Ser73, Ser100) Recombinant Rabbit Monoclonal Antibody (23GB4495)

View all (3) C-Jun/D-Jun antibodies

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Phospho-C-Jun/D-Jun (Ser73, Ser100) Recombinant Rabbit Monoclonal Antibody (23GB4495)

Product Details

MA5-52704

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB4495

Immunogen

A synthesized peptide derived from human Phospho-c-Jun (Ser73)+JunD (Ser100) (66-80AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3 mg/mL

Amount

300 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3249181

Target Information

C-Jun/D-Jun are members of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activator Protein 1; AH119; AP-1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; C-JUN; CJUN; Enhancer-Binding Protein AP1; immediate early; JUN; Jun A; Jun Activation Domain Binding Protein; jun D proto-oncogene; Jun Oncogene; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; Jun Proto-Oncogene, AP-1 Transcription Factor Subunit; JunD-FL isoform; P39; Proto-oncogene c-Jun; Proto-Oncogene CJun; Transcription Factor AP-1; Transcription Factor AP-1 Subunit Jun; Transcription factor AP-1 subunit JunD; Transcription Factor Jun; transcription factor jun-D; Transcription factor JunD; unnamed protein product; V-Jun Avian Sarcoma Virus 17 Oncogene Homolog; v-jun sarcoma virus 17 oncogene homolog

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Gene Aliases: AP-1; AP1; c-Jun; cJUN; JUN; Jun-d; Junc; JUND; Jund1; p39; Rjg-9

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UniProt ID: (Human) P05412, (Human) P17535, (Rat) P17325, (Mouse) P05627, (Rat) P52909, (Mouse) P15066

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Entrez Gene ID: (Human) 3725, (Human) 3727, (Rat) 24516, (Mouse) 16476, (Rat) 24518, (Mouse) 16478

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding GTPase activator activity protein binding enzyme binding ubiquitin protein ligase binding cAMP response element binding identical protein binding ubiquitin-like protein ligase binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding general transcription initiation factor binding sequence-specific double-stranded DNA binding transcription cofactor binding transcription coactivator activity ligand-dependent nuclear receptor binding sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding protein homodimerization activity transcription regulatory region DNA binding poly(A) RNA binding protein heterodimerization activity HMG box domain binding basic leucine zipper transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis microglial cell activation liver development positive regulation of endothelial cell proliferation outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process transforming growth factor beta receptor signaling pathway JNK cascade cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus positive regulation of epithelial cell migration release from viral latency monocyte differentiation axon regeneration response to endoplasmic reticulum stress leading edge cell differentiation response to muscle stretch regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA binding negative regulation of neuron apoptotic process negative regulation by host of viral transcription positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation response to steroid hormone regulation of cell cycle SMAD protein signal transduction eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cellular response to anisomycin integrated stress response signaling positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of DNA-templated transcription, initiation osteoblast development transcription from RNA polymerase II promoter circadian rhythm response to light stimulus response to mechanical stimulus gene expression response to lipopolysaccharide positive regulation of peroxisome proliferator activated receptor signaling pathway positive regulation of macrophage activation response to peptide hormone positive regulation of osteoblast differentiation cellular response to fatty acid cellular response to hypoxia response to forskolin release of cytochrome c from mitochondria transcription, DNA-templated SMAD protein import into nucleus aging learning positive regulation of cell proliferation response to radiation cellular process response to organic substance response to organic cyclic compound negative regulation of protein autophosphorylation response to cytokine response to drug response to hydrogen peroxide positive regulation of neuron apoptotic process positive regulation of monocyte differentiation positive regulation of DNA replication positive regulation of smooth muscle cell proliferation cellular response to potassium ion starvation response to cAMP membrane depolarization negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress cellular response to hormone stimulus positive regulation of GTPase activity positive regulation of cell differentiation regulation of cell death
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