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Invitrogen
HIV1 Vif VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1421)
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Product Details
MA5-54351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1421
Immunogen
Recombinant HIV-1 Vif/SOR protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
The HIV-1 viral infectivity factor (Vif) is a crucial protein for the efficient replication of the virus, particularly in non-permissive cells such as lymphocytes and macrophages. Vif is a basic phosphoprotein with a molecular weight of approximately 23,000 Daltons. Its primary function is to counteract the host cellular antiviral protein APOBEC3G, which induces hypermutations in the viral DNA, thereby inhibiting viral replication. Vif achieves this by targeting APOBEC3G for ubiquitination and subsequent degradation, thus preventing it from incorporating into new virions. Structurally, Vif interacts with the cellular ubiquitin-proteasome machinery to facilitate the degradation of APOBEC3G. This interaction is essential for Vif's role in viral replication and immune evasion. Additionally, Vif has been shown to suppress the production of type I interferon by targeting the immune signaling molecule STING, further aiding in immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIV-1
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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