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Invitrogen
HCMV US28 VHH-His Recombinant Alpaca Monoclonal Antibody (Iv0102)
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Product Details
MA562848
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Iv0102
Immunogen
Recombinant HCMV US28 protein
Conjugate
Form
Liquid
Concentration
0.84 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HCMV US28 is a viral chemokine receptor encoded by the Human Cytomegalovirus (HCMV) classified among the seven-transmembrane G-protein-coupled receptors with constitutive ligand-independent signaling activity. This receptor is known for its ability to bind a broad range of chemokines including both CC and CX_3C motifs facilitating viral immune evasion and cell-cell adhesion processes. US28 plays a significant role in HCMV pathogenesis contributing to viral persistence and influencing the transcriptional regulation of oncogenic pathways within infected cells. The receptor's constitutive activation results in hijacked cellular signaling pathways that promote cell proliferation and survival making US28 a target of interest in therapeutic research for combating HCMV-associated disorders including cardiovascular diseases and cancers. Understanding its structure and function has crucial implications in the development of antiviral strategies aimed at disrupting HCMV signaling and infection mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CMV chemokine receptor; G-protein coupled receptor US28
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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