Sequence of this protein is as follows: MARVPLGRSL TLSPRLEHNG MTSAHHNFRL PGSRDSPASA SQVAEIIDLE WYEKSEETHA SQIELLETSS TQEPLNASEA FCPRDCMVPV VFPGPVSQEG CCQFTCELLK HIMYQRQQLP LPYEQLKHFY RKPSPQAEEM LKKKPRATTE VSSRKCQQAL AELESVLSHL EDFFARTLVP RVLILLGGNA LSPKEFYELD LSLLAPYSVD QSLSTAACLR RLFRAIFMAD AFSELQAPPL MGTVVMAQGH RNCGEDWFRP KLNYRVPSRG HKLTVTLSCG RPSIRTTAWE DYIWFQAPVT FKGFRE
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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Protein Aliases: Caught by MAD2 protein; MAD2L1-binding protein; p31(comet); RP1-261G23.6
Gene Aliases: 0610009D16Rik; 2510031P20Rik; AU018945; AW550977; C76045; CMT2; CMT2A; CMT2B; KIAA0110; MAD2L1BP; Mad2lbp; mKIAA0110