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Invitrogen
MAD2L2 Polyclonal Antibody
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Product Details
PA5-76445
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human MAD2B/MAD2B/MAD2L2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; Mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; REV7 homolog; RP3-330O12.4
Gene Aliases: 2310033C13Rik; G1-453-4; MAD2B; MAD2L2; POLZ2; repro22; REV7
UniProt ID: (Human) Q9UI95, (Mouse) Q9D752
Entrez Gene ID: (Human) 10459, (Mouse) 71890
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
double-strand break repair
transcription, DNA-templated
actin filament organization
mitotic nuclear division
mitotic spindle assembly checkpoint
negative regulation of epithelial to mesenchymal transition
negative regulation of transcription by competitive promoter binding
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein catabolic process
error-prone translesion synthesis
DNA damage response, signal transduction resulting in transcription
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
cell division
negative regulation of canonical Wnt signaling pathway
negative regulation of ubiquitin protein ligase activity
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of transcription regulatory region DNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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