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Immunogen sequence: PGIKITVNP ESKAVLAGQF VKLCCRATGH PFVQYQWFKM NKEIPNGNTS ELIFNAVHVK DAGFYVCRVN NNFTFEFSQW SQLDVCDIPE SFQRSVDGVS ESKLQICVEP TSQKLMPGST LVLQCVAVGS PIPHYQWFKN ELPLTHETKK LYMVPYVDLE HQGTYWCHVY NDRDSQDSKK VEIIIDELNN LGHPDNKEQT TDQPLAKDKV ALLIGNMNYR EHPKLKAPLV DVYELTNLLR QLDFKVVSLL DLTEYEMRNA VDEFLLLLDK GVYGLLYYAG HGYENFGNSF MVPVDAPNPY RSENCLCVQN ILKLMQEKET GLNVFLL (125-450 aa encoded by BC030143 )
MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma (Uren et al., 2000). MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF-kappaB.
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Protein Aliases: caspase-like protein; DKFZp434L132; MALT lymphoma-associated translocation; malt-1; malt1; MALT1 paracaspase; MALT1 protease; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; Paracaspase; paracaspase 1; paracaspase-1
Gene Aliases: A630046N12; D430033E09Rik; IMD12; MALT1; MLT; MLT1; PCASP1
Molecular Function: cysteine protease