MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma (Uren et al., 2000). MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF-kappaB.
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Protein Aliases: caspase-like protein; DKFZp434L132; MALT lymphoma-associated translocation; malt-1; malt1; MALT1 paracaspase; MALT1 protease; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; Paracaspase; paracaspase 1; paracaspase-1
Gene Aliases: A630046N12; D430033E09Rik; IMD12; MALT1; MLT; MLT1; PCASP1
Molecular Function: cysteine protease