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Proteintech
MAN1B1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
15243-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAN1B1 fusion protein Ag7455
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LFLRKAEDFG NRLMPAFRTP SKIPYSDVNI GTGVAHPPRW TSDSTVAEVT SIQLEFRELS RLTGDKKFQE AVEKVTQHIH GLSGKKDGLV PMFINTHSGL FTHLGVFTLG ARADSYYEYL LKQWIQGGKQ ETQLLEDYVE AIEGVRTHLL RHSEPSKLTF VGELAHGRFS AKMDHLVCFL PGTLALGVYH GLPASHMELA QELMETCYQM NRQMETGLSP EIVHFNLYPQ PGRRDVEVKP ADRHNLLRPE TVESLFYLYR VTGDRKYQDW GWEILQSFSR FTRVPSGGYS SINNVQDPQK PEPRDKMESF FLGETLKYLF LLFSDDPNLL SLDAYVFNTE AHPLPIWTPA
Target Information
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3.2.1.113; endoplasmic Reticulum Class I alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; ER alpha 1,2-mannosidase; Man9GlcNAc2-specific processing alpha-mannosidase; RP11-350O14.2; unnamed protein product
Gene Aliases: ERMAN1; ERManI; MANA-ER; MRT15
UniProt ID: (Human) Q9UKM7
Entrez Gene ID: (Human) 11253
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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