This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: ETDPLNEPWE EEWTLLGKEE LSGSLLQSVQ EALEERSLTI RSASEFQELD SPDDTMGTIK RAPFLGPLPT DPPAEEPLSS PPGTLPPPPS GPNSSPLLPT AWATMKQRE
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; GC kinase; Germinal center kinase; germinal centre kinase (GC kinase); MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Mitogen-activated protein kinase kinase kinase kinase 2; Rab8 interacting protein; Rab8-interacting protein
Gene Aliases: BL44; GCK; MAP4K2; RAB8IP
UniProt ID: (Human) Q12851
Entrez Gene ID: (Human) 5871