The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Protein Aliases: c Jun N terminal kinase 3; c-Jun N-terminal kinase 3; JNK3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; mitogen activated protein kinase 10; Mitogen-activated protein kinase 10; p493F12; p54-beta; p54bSAPK; PRKM10; SAPK-beta; SAPK/Erk/kinase 2; SAPK1b; Stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3
Gene Aliases: C230008H04Rik; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; p493F12; p54bSAPK; PRKM10; SAPb; SAPK(beta); SAPK1B; SAPKC; Serk2