PA5-28199 targets MAPKAP Kinase 3 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-28199 immunogen is recombinant fragment corresponding to a region within amino acids 89 and 382 of Human MAPKAP Kinase 3.
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This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
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Protein Aliases: 3PK; Chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAP3; MAPKAPK-3; mitogen activated protein kinase-activated protein kinase 3; MK-3
Gene Aliases: 3PK; AI874665; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MAPKAPK3; MapkKapk3; MK-3; MK3