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Search Thermo Fisher Scientific
It is not recommended to aliquot this antibody.
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ELKL motif serine-threonine protein kinase 3; ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; MARK1; mark1 {ECO:0000312|RGD:619882}; Par-1c; PAR1 homolog c; Serine/threonine-protein kinase MARK1
Gene Aliases: AW491150; B930025N23Rik; Emk3; KIAA1477; MARK; MARK1; mKIAA1477; mPar-1c; Par-1c; Par1c
UniProt ID: (Human) Q9P0L2, (Mouse) Q8VHJ5, (Rat) O08678
Entrez Gene ID: (Human) 4139, (Mouse) 226778, (Rat) 117016
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