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Invitrogen
MATN3 Polyclonal Antibody
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Product Details
PA5-145085
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 320-401. Recombinant protein control fragment (Product #RP-109824).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ICVNDRSGSY HCECYEGYTL NEDRKTCSAQ DKCALGTHGC QHICVNDRTG SHHCECYEGY TLNADKKTCS VRDKCALGSH GC
Antigen sequence identity: Mouse 84%; Rat 91%
Target Information
Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B14.5b; CI-B14.5b; Matrilin-3; matrilin-3 lacking EGF-1 domain; NADHDH2; NDUFC2; unnamed protein product
Gene Aliases: DIPOA; EDM5; HOA; MATN3; OADIP; OS2; SEMDBCD
UniProt ID: (Human) O15232
Entrez Gene ID: (Human) 4148
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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