Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CpG binding domain 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
Gene Aliases: AI181826; AU019209; MBD3