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Proteintech
MBD3 Polyclonal Antibody
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Product Details
14258-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MBD3 Fusion Protein Ag5531 (1-259 aa encoded by BC043619)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERKSPSGK KFRSKPQLAR YLGGSMDLST FDFRTGKMLM SKMNKSRQRV RYDSSNQVKG KPDLNTALPV RQTASIFKQP VTKITNHPSN KVKSDPQKAV DQPRQLFWEK KLSGLNAFDI AEELVKTMDL PKGLQGVGPG CTDETLLSAI ASALHTSTMP ITGQLSAAVE KNPGVWLNTT QPLCKAFMVT DEDIRKQEEL VQQVRKRLEE ALMADMLAHV EELARDGEAP LDKACAEDDD EEDEEEEEEE PDPDPEMEHV (1-259 aa encoded by BC043619)
Target Information
Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CpG binding domain 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
Gene Aliases: AI181826; AU019209; MBD3
UniProt ID: (Human) O95983, (Mouse) Q9Z2D8
Entrez Gene ID: (Human) 53615, (Mouse) 17192, (Rat) 362834
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
methylation-dependent chromatin silencing
transcription, DNA-templated
brain development
heart development
aging
tissue development
histone acetylation
histone deacetylation
response to nutrient levels
response to estradiol
ATP-dependent chromatin remodeling
regulation of DNA methylation
embryonic organ development
regulation of signal transduction by p53 class mediator
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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