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Invitrogen
MBD3 Polyclonal Antibody
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Product Details
PA5-104228
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MBD3(Accession O95983), corresponding to amino acid residues E240-A260.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MBD3.
Target Information
Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CpG binding domain 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; unnamed protein product
Gene Aliases: AI181826; AU019209; MBD3
UniProt ID: (Human) O95983, (Mouse) Q9Z2D8
Entrez Gene ID: (Human) 53615, (Mouse) 17192, (Rat) 362834
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
ventricular cardiac muscle tissue development
chromatin remodeling
methylation-dependent chromatin silencing
tissue development
response to nutrient levels
response to estradiol
regulation of gene expression, epigenetic
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
embryonic organ development
response to bisphenol A
regulation of stem cell differentiation
brain development
heart development
aging
response to organic cyclic compound
histone acetylation
ATP-dependent chromatin remodeling
regulation of DNA methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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