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Invitrogen
MBP Polyclonal Antibody
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FIGURE: 1 / 4
MBP Antibody (PA5-79642) in IHC (P)
Immunohistochemistry (Paraffin) analysis of MBP in paraffin-embedded section of rat brain tissues using MBP Polyclonal Antibody (Product # PA5-79642). Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution ) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight... View More
Product Details
PA5-79642
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Myelin Basic Protein (182-197aa KLGGRDSRSGSPMARR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat brain tissue, mouse brain tissue. IHC: mouse cerebellum tissue, mouse brain tissue, mouse hippocampus tissue, mouse cerebral cortex tissue, rat cerebellum tissue, rat brain tissue, rat hippocampus tissue, rat cerebral cortex tissue.
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 17.3K myelin basic protein; golli mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer; unnamed protein product
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi
UniProt ID: (Human) P02686, (Rat) Q505J1, (Mouse) P04370
Entrez Gene ID: (Human) 4155, (Rat) 24547, (Mouse) 17196
MAPK cascade
immune response
chemical synaptic transmission
central nervous system development
sensory perception of sound
axon ensheathment
response to toxic substance
substantia nigra development
positive regulation of interleukin-6 production
negative regulation of heterotypic cell-cell adhesion
maintenance of blood-brain barrier
myelination
membrane organization
positive regulation of metalloendopeptidase activity
positive regulation of chemokine (C-X-C motif) ligand 2 production
aging
response to progesterone
response to tumor necrosis factor
response to mercury ion
negative regulation of axonogenesis
response to fatty acid
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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