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Product Details
PA5-20759
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide near the amino terminus of human MC4R.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152201
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-20759 can be used with blocking peptide PEP-0873.
Target Information
Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MC4; MC4 receptor; MC4-R; Melanocortin receptor 4
Gene Aliases: Mc4-r; MC4R
UniProt ID: (Human) P32245, (Rat) P70596, (Mouse) P56450
Entrez Gene ID: (Human) 4160, (Rat) 25635, (Mouse) 17202
diet induced thermogenesis
energy reserve metabolic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
feeding behavior
insulin secretion
positive regulation of cAMP biosynthetic process
response to insulin
positive regulation of bone resorption
negative regulation of feeding behavior
regulation of grooming behavior
G-protein coupled receptor signaling pathway
regulation of metabolic process
regulation of feeding behavior
signal transduction
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