Immunogen sequence: SVESPNLTTP ITSNPTDTRK ITSGNSSNSP NAEVMAVQKK LDSIIDLTKE GLSNCNTESP VSPLESHSKA ASNSKETTPL AQNAVQVPES FEHLPPLPEP PAPL
Highest antigen sequence identity to the following orthologs: Mouse - 58%, Rat - 40%.
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone 'Lys-9' trimethylation activity (Probable).
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Protein Aliases: Activating transcription factor 7-interacting protein 2; ATF7-interacting protein 2; MBD1-containing chromatin associated factor 2; MBD1-containing chromatin-associated factor 2; MCAF2
Gene Aliases: ATF7IP2; MCAF2
UniProt ID: (Human) Q5U623
Entrez Gene ID: (Human) 80063