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MCK10 Polyclonal Antibody
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Product Details
BS-0671R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CD167a/MCK10, amino acids 21-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR1d; discoidin domain receptor family, member 1; Discoidin receptor tyrosine kinase; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; HGK2; juxtamembrane region; Mammary carcinoma kinase 10; MCK-10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase receptor type 4; neurotrophic tyrosine kinase, receptor, type 4; protein-tyrosine kinase 3; Protein-tyrosine kinase 3A; Protein-tyrosine kinase MPK-6; protein-tyrosine kinase PTK-3; Protein-tyrosine kinase RTK-6; PTK3A protein tyrosine kinase 3A; TRK E; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; unnamed protein product
Gene Aliases: 6030432F18; AI323681; CAK; CD167; CD167a; DDR; DDR1; Drd1; EDDR1; HGK2; MCK10; Mpk6; NEP; NTRK4; PTK3; PTK3A; PTK3D; RTK6; TRKE
UniProt ID: (Human) Q08345, (Mouse) Q03146
Entrez Gene ID: (Human) 780, (Mouse) 12305, (Rat) 25678
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
collagen binding
ATP binding
kinase activity
transferase activity
protein tyrosine kinase collagen receptor activity
metal ion binding
transferase activity, transferring phosphorus-containing groups
molecular_function
transmembrane signal receptor
regulation of cell growth
regulation of cell-matrix adhesion
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
female pregnancy
embryo implantation
lactation
cell proliferation
negative regulation of cell proliferation
regulation of extracellular matrix disassembly
positive regulation of neuron projection development
smooth muscle cell migration
collagen-activated tyrosine kinase receptor signaling pathway
peptidyl-tyrosine autophosphorylation
ear development
wound healing, spreading of cells
protein autophosphorylation
positive regulation of protein kinase B signaling
branching involved in mammary gland duct morphogenesis
mammary gland alveolus development
smooth muscle cell-matrix adhesion
axon development
neuron projection extension
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
organ regeneration
skin development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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