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Proteintech
MCRS1 Polyclonal Antibody
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Product Details
11362-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MCRS1 Fusion Protein Ag1904 (1-462 aa encoded by BC011794)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDKDSQGLL DSSLMASGTA SRSEDEESLA GQKRASSQAL GTIPKRRSSS RFIKRKKFDD ELVESSLAKS STRAKGASGV EPGRCSGSEP SSSEKKKVSK APSTPVPPSP APAPGLTKRV KKSKQPLQVT KDLGRWKPAD DLLLINAVLQ TNDLTSVHLG VKFSCRFTLR EVQERWYALL YDPVISKLAC QAMRQLHPEA IAAIQSKALF SKAEEQLLSK VGSTSQPTLE TFQDLLHRHP DAFYLARTAK ALQAHWQLMK QYYLLEDQTV QPLPKGDQVL NFSDAEDLID DSKLKDMRDE VLEHELMVAD RRQKREIRQL EQELHKWQVL VDSITGMSSP DFDNQTLAVL RGRMVRYLMR SREITLGRAT KDNQIDVDLS LEGPAWKISR KQGVIKLKNN GDFFIANEGR RPIYIDGRPV LCGSKWRLSN NSVVEIASLR FVFLINQDLI ALIRAEAAKI TPQ (1-462 aa encoded by BC011794)
Target Information
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1; nucleolar protein
Gene Aliases: C78274; ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78
UniProt ID: (Human) Q96EZ8, (Mouse) Q99L90
Entrez Gene ID: (Human) 10445, (Rat) 300222, (Mouse) 51812
telomere maintenance
regulation of DNA replication
DNA repair
regulation of DNA repair
DNA recombination
chromatin organization
chromatin remodeling
cellular response to DNA damage stimulus
positive regulation of macromolecule metabolic process
regulation of telomere maintenance
regulation of chromosome organization
protein modification process
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
positive regulation of nucleobase-containing compound metabolic process
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
regulation of cell cycle
regulation of DNA strand elongation
negative regulation of telomere maintenance via telomere lengthening
positive regulation of telomere maintenance in response to DNA damage
positive regulation of protein localization to nucleolus
biological_process
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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