Search
Invitrogen
MCU Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
MCU Antibody (PA5-68153) in IHC (P)
Immunohistochemical analysis of CCDC109A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with MCU Polyclonal Antibody (Product # PA5-68153) at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the ch... View More
Product Details
PA5-68153
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human MCU.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.42% potassium phosphate, pH 7.3, with 30% glycerol, 0.87% NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcium uniporter protein, mitochondrial; coiled-coil domain containing 109A; Coiled-coil domain-containing protein 109A; HsMCU; unnamed protein product
Gene Aliases: 2010012O16Rik; AV064928; C10orf42; CCDC109A; D130073L02Rik; Gm64; HsMCU; MCU
UniProt ID: (Human) Q8NE86, (Mouse) Q3UMR5
Entrez Gene ID: (Human) 90550, (Mouse) 215999
generation of precursor metabolites and energy
ion transport
calcium ion transport
mitochondrial calcium ion transport
cell proliferation
cell migration
calcium-mediated signaling
positive regulation of insulin secretion
ion transmembrane transport
calcium ion transmembrane import into mitochondrion
glucose homeostasis
protein oligomerization
mitochondrial calcium ion homeostasis
positive regulation of mitochondrial calcium ion concentration
calcium ion transmembrane transport
cellular response to calcium ion starvation
positive regulation of neutrophil chemotaxis
positive regulation of mitochondrial fission
transport
protein complex oligomerization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support