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MD-1 Polyclonal Antibody
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FIGURE: 1 / 2
MD-1 Antibody (600-401-CS2) in IHC (P)
Immunohistochemistry of MD-1 antibody. Tissue: human spleen tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: MD-1 antibody at 2.5 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: MD-1 is secreted. Staining: MD-1 is stained with hematoxylin purple nuclear counterstain.
Product Details
600-401-CS2
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-MD-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human MD-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MD-1, also known as LY86, is a glycoprotein involved in innate immunity. It is a component of the RP105/MD-1 complex, which is expressed primarily in immune cells like B-cells. MD-1 is structurally similar to MD-2, sharing only 16% sequence identity, yet both are implicated in lipopolysaccharide recognition. The protein contains the ML (MD-2-related lipid-recognition) domain, which is conserved across various species and mediates diverse biological functions by interacting with specific lipids. Structurally, MD-1 is characterized by a beta-rich fold consisting of multiple strands, which is integral to its biological activities. Though MD-1 mainly associates with RP105, its role in lipid recognition suggests functional similarities with proteins such as GM2A and NPC2, implying participation in broader immune signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ly-86; Lymphocyte antigen 86; MD-1, RP105-associated; product associated with RP105; Protein MD-1; RP1-80N2.1
Gene Aliases: dJ80N2.1; LY86; MD-1; MD1; MMD-1
UniProt ID: (Human) O95711, (Mouse) O88188
Entrez Gene ID: (Human) 9450, (Rat) 291359, (Mouse) 17084
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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