This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: LPTTMTGVMG LEPSSYKTSV YRQQQPAVPQ GQRLRQQLQA KIQSQGMLGQ SSVHQMTPSS SYGLQTSQGY TPYVSHVGLQ QHTGPAGTMV PPSYSSQPYQ STHPSTNPTL VDPTRHLQQR PSGYVHQQAP TYGHGLTS
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; human opposite paired; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; mediator of RNA polymerase II transcription, subunit 12 homolog; OPA-containing protein; OPA-containing protein 1; putative mediator subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; thyroid hormone receptor-associated protein, 230 kDa subunit; Trap230; trinucleotide repeat containing 11 (THR-associated protein); trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); Trinucleotide repeat-containing gene 11 protein
Gene Aliases: 230kDa; ARC240; CAGH45; FGS1; HOPA; KIAA0192; MED12; MED12S; Mopa; OHDOX; OKS; OPA-1; OPA1; TNRC11; TRAP230
Molecular Function: general transcription factor