This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25267-PEP)..
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA-binding protein Mel-18; MGC10545; Polycomb group RING finger protein 2; RING finger protein 110; Zinc finger protein 144
Gene Aliases: MEL-18; MEL18; PCGF2; RNF110; ZNF144
UniProt ID: (Human) P35227
Entrez Gene ID: (Human) 7703
Molecular Function: ubiquitin-protein ligase