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Proteintech
MEN1 Polyclonal Antibody
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Product Details
15159-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEN1 Fusion Protein Ag7253 (226-575 aa encoded by BC002544)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
66 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QKLLWLLYD LGHLERYPMA LGNLADLEEL EPTPGRPDPL TLYHKGIASA KTYYRDEHIY PYMYLAGYHC RNRNVREALQ AWADTATVIQ DYNYCREDEE IYKEFFEVAN DVIPNLLKEA ASLLEAGEER PGEQSQGTQS QGSALQDPEC FAHLLRFYDG ICKWEEGSPT PVLHVGWATF LVQSLGRFEG QVRQKVRIVS REAEAAEAEE PWGEEAREGR RRGPRRESKP EEPPPPKKPA LDKGLGTGQG AVSGPPRKPP GTVAGTARGP EGGSTAQVPA PAASPPPEGP VLTFQSEKMK GMKELLVATK INSSAIKLQL TAQSQVQMKK QKVSTPSDYT LSFLKRQRKG L (226-575 aa encoded by BC002544)
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Menin
Gene Aliases: MEAI; MEN1; SCG2
UniProt ID: (Human) O00255
Entrez Gene ID: (Human) 4221
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
negative regulation of protein phosphorylation
osteoblast development
DNA repair
chromatin organization
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
negative regulation of cell proliferation
response to UV
response to gamma radiation
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
T-helper 2 cell differentiation
negative regulation of osteoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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