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Proteintech
MEPCE Polyclonal Antibody, CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-14917
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEPCE fusion protein Ag6733
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SGSLSAPPA ASVISAPPSS SSRHRKRRRT SSKSEAGARG GGQGSKEKGR GSWGGRHHHH HPLPAAGFKK QQRKFQYGNY CKYYGYRNPS CEDGRLRVLK PEWFRGRDVL DLGCNVGHLT LSIACKWGPS RMVGLDIDSR LIHSARQNIR HYLSEELRLP PQTLEGDPGA EGEEGTTTVR KRSCFPASLT ASRGPIAAPQ VPLDGADTSV FPNNVVFVTG NYVLDRDDLV EAQTPEYDVV LCLSLTKWVH LNWGDEGLKR MFRRIYRHLR PGGILVLEPQ PWSSYGKRKT LTETIYKNYY RIQLKPEQFS SYLTSPDVGF SSYELVATPH NTSKGFQRPV YLFHKARSPS H
Target Information
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bicoid-interacting protein 3 homolog; bin3 homolog; bin3, bicoid-interacting 3, homolog; FLJ20257; unnamed protein product
Gene Aliases: BCDIN3
UniProt ID: (Human) Q7L2J0
Entrez Gene ID: (Human) 56257
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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