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Immunogen sequence: RVGLWKIKDNP LIQPPYEVCM KGIPYIAAYQ KELAHSQPAV QPRLKLLLMG HKAAGKTLLR HCLTEERVEG CPGGGDKEKC YPPSP
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: leucine rich repeat containing 65; Malignant fibrous histiocytoma-amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1; malignant fibrous histiocytoma-amplified sequences with leucine-rich tandem repeats 1; MFH-amplified sequences with leucine-rich tandem repeats 1
Gene Aliases: LRRC65; MASL1; MFHAS1
UniProt ID: (Human) Q9Y4C4
Entrez Gene ID: (Human) 9258
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