Immunogen sequence: RVGLWKIKDNP LIQPPYEVCM KGIPYIAAYQ KELAHSQPAV QPRLKLLLMG HKAAGKTLLR HCLTEERVEG CPGGGDKEKC YPPSP
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH.
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Protein Aliases: leucine rich repeat containing 65; Malignant fibrous histiocytoma-amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1; malignant fibrous histiocytoma-amplified sequences with leucine-rich tandem repeats 1; MASL1; MFH-amplified sequences with leucine-rich tandem repeats 1
Gene Aliases: LRRC65; MASL1; MFHAS1
UniProt ID: (Human) Q9Y4C4
Entrez Gene ID: (Human) 9258