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Proteintech
MFN1 Polyclonal Antibody
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Product Details
13798-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MFN1 Fusion Protein Ag4762 (27-351 aa encoded by BC040557)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EFVTEGSHF VEATYKNPEL DRIATEDDLV EMQGYKDKLS IIGEVLSRRH MKVAFFGRTS SGKSSVINAM LWDKVLPSGI GHITNCFLSV EGTDGDKAYL MTEGSDEKKS VKTVNQLAHA LHMDKDLKAG CLVRVFWPKA KCALLRDDLV LVDSPGTDVT TELDSWIDKF CLDADVFVLV ANSESTLMNT EKHFFHKVNE RLSKPNIFIL NNRWDASASE PEYMEDVRRQ HMERCLHFLV EELKVVNALE AQNRIFFVSA KEVLSARKQK AQGMPESGVA LAEGFHARLQ EFQNFEQIFE ECISQSAVKT KFEQHTIRAK QILATV (27-351 aa encoded by BC040557)
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1
Gene Aliases: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; Fzo1b; hfzo1; hfzo2; HR2; MFN1; mKIAA4032
UniProt ID: (Human) Q8IWA4, (Rat) Q8R4Z9, (Mouse) Q811U4
Entrez Gene ID: (Human) 55669, (Rat) 192647, (Mouse) 67414
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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