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Invitrogen

MFN2 Polyclonal Antibody

View all (40) MFN2 antibodies

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MFN2 Polyclonal Antibody

Product Details

PA5-89321

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 70-260 of mouse Mitofusin 2 (NP_5734642)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.38 mg/mL

Amount

138 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805491

Product Specific Information

Positive Samples: Mouse brain, Rat brain; Cellular Location: Mitochondrion outer membrane, Multi-pass membrane protein

Immunogen sequence: TTEEQVLDVK GYLSKVRGIS EVLARRHMKV AFFGRTSNGK STVINAMLWD KVLPSGIGHT TNCFLRVGGT DGHEAFLLTE GSEEKKSVKT VNQLAHALHQ DEQLHAGSMV SVMWPNSKCP LLKDDLVLMD SPGIDVTTEL DSWIDKFCLD ADVFVLVANS ESTLMQTEKQ FFHKVSERLS RPNIFILNNR W

Target Information

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CPRP 1; HRP1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; MARF; GTP-binding transmembrane protein; MARF; mitochondrial GTP-binding transmembrane protein; MFN 2; mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; mitofusin-2-like; Mitofusin2; related to proliferation of VSMCs; transmembrane GTPase MFN2; unnamed protein product

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Gene Aliases: CMT2A; CMT2A2; CMT2A2A; CMT2A2B; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; MARF; MSL

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UniProt ID: (Human) O95140, (Mouse) Q80U63

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Entrez Gene ID: (Human) 9927, (Rat) 64476, (Mouse) 170731

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Function(s)
GTPase activity protein binding GTP binding ubiquitin protein ligase binding small GTPase binding identical protein binding proteoglycan binding GTPase binding
Process(es)
blastocyst formation mitochondrion organization mitochondrial membrane organization spermatogenesis mitochondrial fusion negative regulation of cell proliferation gonad development male gonad development aerobic respiration response to manganese ion positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of hydrogen peroxide biosynthetic process positive regulation of mitochondrial membrane potential response to muscle activity response to nutrient levels response to testosterone protein localization to pre-autophagosomal structure negative regulation of cell cycle negative regulation of cell size positive regulation of glucose import negative regulation of Ras protein signal transduction positive regulation of insulin receptor signaling pathway response to cadmium ion intracellular distribution of mitochondria camera-type eye morphogenesis negative regulation of smooth muscle cell proliferation response to axon injury mitochondrial calcium ion homeostasis response to calcium ion response to electrical stimulus mitochondrion localization negative regulation of glial cell proliferation negative regulation of sarcomere organization positive regulation of dendritic spine morphogenesis parkin-mediated mitophagy in response to mitochondrial depolarization response to fatty acid cellular response to manganese ion cellular response to glucose stimulus cellular response to testosterone stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to mercaptoethanol negative regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission positive regulation of cold-induced thermogenesis positive regulation of cellular respiration negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process response to L-arginine negative regulation of vascular smooth muscle cell proliferation positive regulation of vascular smooth muscle cell proliferation cellular response to L-glutamate response to D-galactose response to flavonoid positive regulation of vascular associated smooth muscle cell apoptotic process response to hypobaric hypoxia positive regulation of ovarian follicle development positive regulation of estradiol secretion positive regulation of progesterone secretion
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