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Invitrogen
MFN2 Polyclonal Antibody
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FIGURE: 1 / 4
MFN2 Antibody (PA5-89321) in IHC (P)
Immunohistochemistry analysis of MFN2 in paraffin-embedded human liver damage. Samples were incubated with MFN2 Polyclonal antibody (Product # PA5-89321). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. 40x lens.
Product Details
PA5-89321
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 70-260 of mouse Mitofusin 2 (NP_5734642)
Conjugate
Form
Liquid
Concentration
1.38 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse brain, Rat brain; Cellular Location: Mitochondrion outer membrane, Multi-pass membrane protein
Immunogen sequence: TTEEQVLDVK GYLSKVRGIS EVLARRHMKV AFFGRTSNGK STVINAMLWD KVLPSGIGHT TNCFLRVGGT DGHEAFLLTE GSEEKKSVKT VNQLAHALHQ DEQLHAGSMV SVMWPNSKCP LLKDDLVLMD SPGIDVTTEL DSWIDKFCLD ADVFVLVANS ESTLMQTEKQ FFHKVSERLS RPNIFILNNR W
Target Information
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CPRP 1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; Hypertension-related protein 1; MFN 2; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2
Gene Aliases: CMT2A; CMT2A2; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; KIAA0214; MARF; MFN2
UniProt ID: (Human) O95140, (Mouse) Q80U63
Entrez Gene ID: (Human) 9927, (Mouse) 170731, (Rat) 64476
blastocyst formation
protein targeting to mitochondrion
autophagy
apoptotic process
response to unfolded protein
mitochondrial membrane organization
multicellular organism development
mitochondrial fusion
protein localization to pre-autophagosomal structure
negative regulation of Ras protein signal transduction
camera-type eye morphogenesis
negative regulation of smooth muscle cell proliferation
mitochondrion localization
cell cycle arrest
blood coagulation
macroautophagy
parkin-mediated mitophagy in response to mitochondrial depolarization
metabolic process
negative regulation of cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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