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Immunogen sequence: TTRAFHRLRL ELLLDTWVSR TREQTFVFTD SPDKGLQERL GSHLVVTNCS AEHSHPALSC KMAAEFDTFL AS
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 88%.
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-1,3-N-acetylglucosaminyltransferase manic fringe; EC 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene Aliases: MFNG
UniProt ID: (Human) O00587
Entrez Gene ID: (Human) 4242
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