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FIGURE: 1 / 1
Positive test controls include: Jurkat, Mouse liver, Mouse spleen. The target is usually found in the following locations: Nucleus.
Immunogen sequence: MLGQPAPLER FASRRPQVLA VRTVCDLVLG KMDKDCEMKR TTLDSPLGKL ELSGCEQGLH EIKLLGKGTS AADAVEVPAP AAVLGGPEPL MQCTAWLNAY FHQPEAIEEF PVPALHHPVF QQESFTRQVL WKLLKVVKFG EVISYQQLAA LAGNPKAARA VGGAMRGNPV PILIPCHRVV CSSGAVGNYS GGLAVKEWLL AHEGHRL
O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 6-O-methylguanine-DNA methyltransferase; methylated DNA protein cysteine methyltransferase; Methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguan; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase
Gene Aliases: Agat; AGT; AI267024; MGMT
UniProt ID: (Human) P16455, (Mouse) P26187
Entrez Gene ID: (Human) 4255, (Mouse) 17314
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