This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: MMEGETNFSS EIEDLAREGD MPIHELLSLY GYGSTVRLPE EDEEEEEEEE EGEDDEDADN DDNSGCSGEN KEENIKDSSG QEDETQSSND DPSQSVASQD AQEI
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Early response 1; hMI-ER1; mesoderm induction early response 1 homolog; mesoderm induction early response 1, transcriptional regulator; Mesoderm induction early response protein 1; RP5-944N15.1
Gene Aliases: ER1; KIAA1610; MI-ER1; MIER1
UniProt ID: (Human) Q8N108
Entrez Gene ID: (Human) 57708
Molecular Function: homeodomain transcription factor