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Invitrogen
MIER3 Polyclonal Antibody
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Product Details
PA5-100614
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MIER3(Accession Q7Z3K6), corresponding to amino acid residues G62-L112.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MIER3.
Target Information
MIER3, known as Mesoderm Induction Early Response 1, Family Member 3, is a gene associated with epithelial-mesenchymal transition (EMT) processes particularly in cancer research. The gene is located on chromosome 7 and has been identified in studies as playing a crucial role in the progression of colorectal and breast cancers. Structurally, MIER3 is involved in chromatin remodeling and histone acetylation, functioning together with HDAC1/2 and Snail proteins. Its expression profile has been characterized using bioinformatics, real-time PCR, and Western blotting, indicating that MIER3 interacts closely with cellular mechanisms that modulate gene expression and cellular differentiation. The gene's role in cancer has been explored through its capacity to induce EMT, which affects tumor metastasis and cell migration, highlighting its potential as a therapeutic target in oncology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mesoderm induction early response 1, family member 3; Mesoderm induction early response protein 3; Mi-er3; unnamed protein product
Gene Aliases: 5730509D14; AU015422; D130064H19Rik; MIER3; RGD1311241
UniProt ID: (Human) Q7Z3K6, (Mouse) Q3UHF3
Entrez Gene ID: (Human) 166968, (Rat) 310086, (Mouse) 218613
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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