PA5-28901 targets MAP4K6 in IF and WB applications and shows reactivity with Human samples.
The PA5-28901 immunogen is recombinant fragment corresponding to a region within amino acids 901 and 1120 of Human MAP4K6.
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This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.
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Protein Aliases: B55; GCK family kinase MINK; hMINK; hMINKbeta; MAP4K6; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; MINK; Misshapen-like kinase 1; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6; serine/threonine protein kinase; YSK2; ZC3
Gene Aliases: B55; MAP4K6; MINK; MINK1; YSK2; ZC3
UniProt ID: (Human) Q8N4C8
Entrez Gene ID: (Human) 50488