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Proteintech
MKL1 Polyclonal Antibody
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Product Details
21166-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MKL1 Fusion Protein Ag15240 (392-741 aa encoded by BC115039)
Conjugate
Form
Liquid
Concentration
0.56 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KAPAATSIL HKAGEVVVAF PAARLSTGPA LVAAGLAPAE VVVATVASSG VVKFGSTGST PPVSPTPSER SLLSTGDENS TPGDTFGEMV TSPLTQLTLQ ASPLQILVKE EGPRAGSCCL SPGGRAELEG RDKDQMLQEK DKQIEALTRM LRQKQQLVER LKLQLEQEKR AQQPAPAPAP LGTPVKQENS FSSCQLSQQP LGPAHPFNPS LAAPATNHID PCAVAPGPPS VVVKQEALQP EPEPVPAPQL LLGPQGPGLI KGVAPPTLIT DSTGTHLVLT VTNKNADSPG LSSGSPQQPS SQPGSPAPAP SAQMDLEHPL QPLFGTPTSL LKKEPPGYEE AMSQQPKQQE N (392-741 aa encoded by BC115039)
Target Information
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: basic SAP and coiled-coil domains; Basic SAP coiled-coil transcription activator; basic, SAP and coiled-coil domain; megakaryoblastic leukemia (translocation) 1 homolog; Megakaryoblastic leukemia 1 protein; Megakaryoblastic leukemia 1 protein homolog; Megakaryocytic acute leukemia protein; Megakaryocytic acute leukemia protein homolog; mixed lineage leukemia; MKL/myocardin-like protein 1; MRTF-A; Myocardin-related transcription factor A
Gene Aliases: AMKL; BSAC; KIAA1438; MAL; MKL1; MRTF-A; MRTFA
UniProt ID: (Human) Q969V6, (Mouse) Q8K4J6
Entrez Gene ID: (Human) 57591, (Mouse) 223701
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
actin binding
actin monomer binding
protein binding
leucine zipper domain binding
DNA-binding transcription factor
transcription, DNA-templated
positive regulation of transcription via serum response element binding
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
negative regulation of apoptotic signaling pathway
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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